Exocytosis-Endocytosis Coupling in the Pancreatic Beta Cell

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Science  10 Aug 1973:
Vol. 181, Issue 4099, pp. 561-562
DOI: 10.1126/science.181.4099.561


The stimulation of the release of insulin by glucose is accompanied by an enhanced uptake of cytochemically demonstrable horseradish peroxidase into endocytotic vesicles within the beta cells. An exocytosis-endocytosis coupling might represent a mechanism by which membrane constituents are recycled within the beta cells under conditions of increased secretory activity.