Differences in Collagen Metabolism between Normal and Osteoarthritic Human Articular Cartilage

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Science  24 Aug 1973:
Vol. 181, Issue 4101, pp. 751-752
DOI: 10.1126/science.181.4101.751


Normal human articular cartilage synthesizes only one type of a chain, which exhibits the chromatographic behavior of the αl(II) chains described for chick and bovine cartilage. Osteoarthritic cartilage, on the other hand, synthesizes in addition a collagen containing α2 chains and β components. The different structural features of the two types of collagen may account for some of the functional defects of osteoarthritic cartilage.

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