Instrumental Conditioning of Large-Magnitude, Daily, 12-Hour Blood Pressure Elevations in the Baboon

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Science  12 Oct 1973:
Vol. 182, Issue 4108, pp. 175-177
DOI: 10.1126/science.182.4108.175


Blood pressure and heart rate were monitored continuously in four baboons during extended exposure to a daily 12-hour conditioning procedure providing food and shock-avoidance as contingent consequences of prespecified increases in diastolic blood pressure. Sustained and significant increases (30 to 40 mm-Hg) in both systolic and diastolic blood pressure were maintained throughout the daily 12-hour conditioning sessions, accompanied by elevated heart rates.