Recovery of Feeding and Drinking by Rats after Intraventricular 6-Hydroxydopamine or Lateral Hypothalamic Lesions

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Science  16 Nov 1973:
Vol. 182, Issue 4113, pp. 717-720
DOI: 10.1126/science.182.4113.717


Rats given intraventricular injections of 6-hydroxydopamine after pretreatment with pargyline become aphagic and adipsic, and show severe loss of brain catecholamines. Like rats with lateral hypothalamic lesions, these animals gradually recover ingestive behaviors, although catecholamine depletions are permanent. Both groups decrease food and water intakes markedly after the administration of α-methyltyrosine, at doses that do not affect the ingestive behaviors of control rats. Thus, both the loss and recovery of feeding and drinking behaviors may involve central catecholamine-containing neurons.