Effects of Dibutyryl Cyclic AMP on Restoration of Function of Damaged Sciatic Nerve in Rats

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Science  16 Nov 1973:
Vol. 182, Issue 4113, pp. 724-725
DOI: 10.1126/science.182.4113.724


In two experiments, the sciatic nerve of rats was either crushed or hemisected, and N6,O2-dibutyryl adenosine 3',5'-monophosphate or saline was injected intramuscularly near the site of the lesion. In both types of nerve damage, the sensorimotor functions of animals treated with N6,O2-dibutyryl adenosine 3',5'-monophosphate returned earlier than did those of saline-treated control animals.