Primary Sequence Dependence of the Deamidation of Rabbit Muscle Aldolase

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Science  11 Jan 1974:
Vol. 183, Issue 4120, pp. 85
DOI: 10.1126/science.183.4120.85


The first-order deamidation half-time of the peptide, Gly-Ser-Asn-His-Gly in phosphate butler, pH 7.4, ionic strength at 0.2, 37.0°C, is 6.4 ± 0.5 days. This compares favorably with the in vivo deamidation half-time of 8 days for this sequence in rabbit muscle aldolase. This fact is discussed with respect to the general hypothesis that sequence-controlled deamidation of glutaminyl and asparaginylresidues is a mechanism by which molecular and organismic development and aging are timed.

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