DNA Synthesis and Mitosis in Well-Differentiated Mammalian Cardiocytes

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Science  18 Jan 1974:
Vol. 183, Issue 4121, pp. 212-213
DOI: 10.1126/science.183.4121.212


Incorporation of [3H]thymidine into nuclei of heart cells of 2-day-old rats indicates that neonatal cardiac cells containing well-aligned myofibrils synthesize DNA. In these highly differentiated cells, neither the presence of contractile proteins nor their organization into myofibrils inhibits either DNA synthesis or mitosis.