Carcinogenicity of Methylchrysenes

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Science  18 Jan 1974:
Vol. 183, Issue 4121, pp. 215-216
DOI: 10.1126/science.183.4121.215


Methylchrysenes are present in tobacco smoke and are suspected to contribute to the tumorigenicity of this inhalant. Chrysene and the six isomeric methylchrysenes were obtained in high purity (〉99.9 percent); they were tested on mouse skin for tumor initiating activity and carcinogenicity. The 3- and 6-methylchrysenes are strong tumor initiators, whereas the other five chrysenes have moderate initiatinig activity. 5-Methylchrysene is a strong carcinogen; the other chrysenes are inactive or weak carcinogens.