Aging Increases Susceptibility of Mouse Skin to DMBA Carcinogenesis Independent of General Immune Status

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Science  18 Jan 1974:
Vol. 183, Issue 4121, pp. 217-218
DOI: 10.1126/science.183.4121.217


The dependence of chemical carcinogenesis on age of target tissue was studied by repeated DMBA-treatment of mouse skin grafted from old and young syngeneic donors to young recipients. Carcinomas developed on 39 percent (1.6/41) of grafts from old donors and on 12 percent (5/41) of grafts from young donors. The incidence of nonskin lymphoid tumors was highest in male recipients bearing grafts from old donors.