Beta Cell Protection to Alloxan Necrosis by Anomers of D-Glucose

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Science  01 Feb 1974:
Vol. 183, Issue 4123, pp. 424
DOI: 10.1126/science.183.4123.424


Various concentrations of either the α or β anomers of D-glucose were injected into fasted rats prior to a diabetogenic dose of alloxan. Plasma concentrations of glucose were measured 24 hours later. There was a significantly greater protection of the pancreatic beta cells by the α anomer of D-glucose as compared to the β anomer, which was evidenced by concentrations of glucose in the plasma, and morphology of beta cells.

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