Tumor Development after 3-Methylcholanthrene in Immunologically Deficient Athymic-Nude Mice

See allHide authors and affiliations

Science  08 Feb 1974:
Vol. 183, Issue 4124, pp. 534-536
DOI: 10.1126/science.183.4124.534


Athymic-nude (nu/nu) mice and normal (nu/+) mice showed no differences in either latent period or incidence of local sarcomas or lung adenomas within 120 days after administration of 3-methylcholanthrene at birth. However, nu/nu mice were incapable of rejecting allogeneic skin grafts for the duration of the experiment. These results argue against an active role of thymus-dependent immunity as a surveillance mechanism preventing tumor development.

Stay Connected to Science