Book Reviews

Cholera Toxin: Interaction of Subunits with Ganglioside GM1

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Science  15 Feb 1974:
Vol. 183, Issue 4125, pp. 656-657
DOI: 10.1126/science.183.4125.656


Vibrio cholerae exotoxin is an aggregate of two different noninterconvertible subunits (molecular weights about 15,000 and about 25,000). Only the smaller subunit reacts with ganglioside GM1, a possible biological receptor. The larger subunit, found only in active toxin molecules, can be eluted with 8 molar urea from insoluble complexes of toxin, ganglioside, and cerebroside.