Gating Currents of the Sodium Channels: Three Ways to Block Them

See allHide authors and affiliations

Science  22 Feb 1974:
Vol. 183, Issue 4126, pp. 753-754
DOI: 10.1126/science.183.4126.753


Preceding the opening of the sodium channels of axon membrane there is a small outward current, gating current, that is probably associated with the molecular rearrangements that open the channels. Gating current is reversibly blocked by three procedures that block the sodium current: (i) internal perfusion with zinc ions, (ii) inactivation of sodium conductance by brief depolarization, and (iii) prolonged depolarization.