Prolactin Receptors in an Estrogen Receptor-Deficient Mammary Carcinoma

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Science  05 Apr 1974:
Vol. 184, Issue 4132, pp. 85-86
DOI: 10.1126/science.184.4132.85


We demonstrate for the first time the presence of specific high-affinity receptors for prolactin in rat mammayy carcinoma. There appear to be no significant differences between normal rat mammary tissue and the transplantable, estrogen receptor-deficient R3230AC tumor with regard to the number of binding sites, the affinity of the receptor for prolactin, or the specificity of binding.

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