Metabolic Differences between Normal and Neoplastic Cells: Effects of Aminonucleoside on Cytoplasmic Messenger RNA

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Science  12 Apr 1974:
Vol. 184, Issue 4133, pp. 160-161
DOI: 10.1126/science.184.4133.160


Treatment of cultured normal human fibroblasts with an adenosine analog (aminonucleoside of puromycin) rapidly inhibits the appearance of cytoplasmic messenger RNA, identified by its polyadenylate sequence. Similar treatment of SV40-transformed fibroblasts does not lead to such an inhibition. Cordycepin. another analog of adenosine. inlhibits polyadenylate-containing cytoplasmic RNA in both types of cell.