Lymphocyte Antigenicity Loss with Retention of Responsiveness

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Science  26 Apr 1974:
Vol. 184, Issue 4135, pp. 464-466
DOI: 10.1126/science.184.4135.464


During culturing at 22°C for more than 4 days, human peripheral blood lymphocytes lose their ability to stimulate allogeneic lymphocytes in mixed lymphocyte cultures. The cells retain their ability to respond to allogeneic lymphocytes or phytohemagglutinin for up to 10 days of culturing. The findings are relevant to reports on successful transplantation of cultured skin.