Heterocytolysis by Macrophages Activated by Bacillus Calmette-Guérin: Lysosome Exocytosis into Tumor Cells

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Science  26 Apr 1974:
Vol. 184, Issue 4135, pp. 468-471
DOI: 10.1126/science.184.4135.468


The cytotoxic activity of activated macrophages against tumorigenic target cells appears to be mediated by lysosomal enzymes of activated macrophage origin. Lysosomes of activated macrophages are secreted directly into the cytoplasm of susceptible target cells, which subsequently undergo heterolysis. This reaction can be inhibited by agents which prevent the exocytosis of macrophage lysosomes (hydrocortisone) or which interfere with the action of lysosomal enzymes (trypan blue).