Somatostatin: Hypothalamic Inhibitor of the Endocrine Pancreas

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Science  26 Apr 1974:
Vol. 184, Issue 4135, pp. 482-484
DOI: 10.1126/science.184.4135.482


Somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone, inhibits basal insulin secretion in fasted cats and rats. In fasted baboons both basal and arginine-stimulated secretion of insulin and glucagon are inhibited. Somatostatin appears to act directly on the endocrine pancreas. The action is dose-related, rapid in onset, and readily reversed.

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