Radioreceptor Assay of Human Chorionic Gonadotropin: Detection of Early Pregnancy

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Science  17 May 1974:
Vol. 184, Issue 4138, pp. 793-795
DOI: 10.1126/science.184.4138.793


A rapid, sensitive, and specific radioreceptor assay for the determination of human chorionic gonadotropin and luteinizing hormone in plasma is described. Plasma membranes of bovine corpora lutea of early pregnancy, which bind biologically active labeled human chorionic gonadotropin, have been used as receptor. Pregnancy could be detected by assaying the gonadotropin in plasma samples obtained from day 6 to 8 after conception.