Inhibition of Experimental Allergic Encephalomyelitis in Rats Severely Depleted of T Cells

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Science  29 Nov 1974:
Vol. 186, Issue 4166, pp. 839-841
DOI: 10.1126/science.186.4166.839


Lewis rats depleted of thymus-derived cells (B rats) failed to develop either experimental allergic encephalomyelitis or antibody against myelin basic protein. Lewis B rats reconstituted with 690 x 106 thymocytes developed experimental allergic encephalomyelitis and levels of antibody against myelin basic protein comparable to those of controls. The Lewis B rat model should be useful in the analysis of the role of thymus-derived cell populations and antibody in the induction of experimental allergic encephalomyelitis.

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