Electron Diffraction of Frozen, Hydrated Protein Crystals

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Science  13 Dec 1974:
Vol. 186, Issue 4168, pp. 1036-1037
DOI: 10.1126/science.186.4168.1036


High-resolution electron diffraction patterns have been obtained from frozen, hydrated catalase crystals to demonstrate the feasibility of using a frozen specimen hydration technique. The use of frozen specimens to maintain the hydration of complex biological structures has certain advantages over previously developed liquid hydration techniques.

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