Skin Carcinogenesis: Cholesterol-5 α, 6 α-Epoxide Hydrase Activity in Mouse Skin Irradiated with Ultraviolet Light

See allHide authors and affiliations

Science  27 Dec 1974:
Vol. 186, Issue 4170, pp. 1216-1217
DOI: 10.1126/science.186.4170.1216


Cholesterol-5α,6α-epoxide hydrase activity was 96 percent greater in skin of hairless mice that were receiving suberythemic ultraviolet light irradiation for 15 weeks than in nonirradiated controls. This enzyme system, which metabolizes cholesterol-5α,6α-epoxide (a known carcinogen), appears to be substrateinducible and is apparently responsible for the concomitant reduction of the sterol carcinogen that occurs prior to tumor induction.

Stay Connected to Science