Partial amino acid sequence of rabbit beta2-microglobulin

See allHide authors and affiliations

Science  21 Mar 1975:
Vol. 187, Issue 4181, pp. 1079-1080
DOI: 10.1126/science.46618


The amino acid sequence of the first 35 residues of a low-molecular-weight protein obtained from the urine of rabbits treated with sodium dichromate was determined and shown to be identical with human beta2-microglobulin in 30 positions. Rabbit beta2-microglobulin, like the human protein, is strikingly homologous to the constant regions of rabbit immunoglobulin G, particularly the CH3 region.