Circadian periodicity a neurospora: alteration by inhibitors of cyclic AMP phosphodiesterase

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Science  21 Nov 1975:
Vol. 190, Issue 4216, pp. 789-790
DOI: 10.1126/science.173018


Three methyl xanthine inhibitors of adenosine 3',5'-monophosphate phosphodiesterase-theophylline, aminophyline, and caffeine-lengthen the period of the circadian conidiation rhythm of Neurospora. The effect are seen in wild-type strains and in three mutant strains with genetically altered period lengths. These results suggest the possible involvement of adenosine 3', 5'-monophosphate in the control of circadian rhythmicity.

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