Reproductive tract lesions in male mice exposed prenatally to diethylstilbestrol

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Science  05 Dec 1975:
Vol. 190, Issue 4218, pp. 991-992
DOI: 10.1126/science.242076


Sixty percent of the male offspring from pregnant mice treated with diethylstilbestrol during gestation were sterile. The affected animals had gonadal changes which included intra-abdominal or fibrotic testes, or both. Additionally, nodular masses in the ampullary region of the reproductive tract were observed in 6 of 24 animals; one of these appeared to be preneoplastic.

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