Messenger RNA induction of fast sodium ion channels in cultured cardiac myoblasts

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Science  23 Jan 1976:
Vol. 191, Issue 4224, pp. 297-299
DOI: 10.1126/science.1246615


Incubation with adult heart messenger RNA caused the appearance of fast sodium ion channels in young myocardial cells whose development has been arrested in vitro. The induction was blocked by cycloheximide, indicating dependence on protein synthesis. Thus, cardiac myoblasts can be made to differentiate in vitro, and membrane properties can be altered by exogenous RNA.

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