Nicotinic acid reduction of plasma volume loss after thermal trauma

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Science  27 Feb 1976:
Vol. 191, Issue 4229, pp. 861-862
DOI: 10.1126/science.1251199


Intravenous administration of nicotinic acid to the anesthetized dog prior to thermal trauma reduced plasma loss at 10 minutes after burn from 7 milliliters per kilogram to less than 2 millimeters per kilogram. During the next 50 minutes plasma loss was the same in treated and untreated animals. An additional dose of nicotinic acid 30 minutes after burn prevented this further loss.

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