Mutagenicity of malonaldehyde, a decomposition product of peroxidized polyunsaturated fatty acids

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Science  27 Feb 1976:
Vol. 191, Issue 4229, pp. 868-869
DOI: 10.1126/science.766187


Incubation of histidine requiring auxotrophs of the bacterium Salmonella typhimurium with malonaldehyde, a three-carbon dialdehyde, produced an increased number of revertants in specific strains. Mutagenesis was only observed in frameshift mutants with normal excision repair and did not occur in those base-pair substitution mutants tested. The results are consistent with the cross-linking of bacterial DNA by malonaldehyde leading to mutagenesis expressed through the error-prone repair system.

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