A serum protein associated with chromatin of cultured fibroblasts

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Science  27 Feb 1976:
Vol. 191, Issue 4229, pp. 869-870
DOI: 10.1126/science.56037


Antibodies to chromatin proteins from human and mouse fibroblasts which have been cultured for more than 25 generations with heterologous serum show specificity for a homologous alpha-serum protein. These results indicate that among the chromatin-associated proteins there is one (or more) which has extensive structural similarity to a serum protein. This is the first direct evidence that a serumlike protein or proteins could be chromatin associated in vivo, as has been suggested by experiments showing in vitro interaction between DNA and certain serum proteins.

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