Hemoglobin synthesis in somatic cell hybrids: independent segregation of the human alpha- and beta-globin genes

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Science  26 Mar 1976:
Vol. 191, Issue 4233, pp. 1262-1264
DOI: 10.1126/science.943846


Hybrid somatic cells containing a partial complement of human chromosomes were used to demonstrate that the human alpha- and beta-globin genes are located on different chromosomes. Two cell lines consisting of a cross of mouse with human fibroblasts contained the human alpha- and not the beta-globin gene, while a cross of human marrow cells with mouse erythroleukemia cells expressed the human beta- but not the alpha-globin gene.