Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs

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Science  30 Apr 1976:
Vol. 192, Issue 4238, pp. 481-483
DOI: 10.1126/science.3854


Tritiated haloperidol and tritiated dopamine label postsynaptic dopamine receptors in mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding. These binding methods provide a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.

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