Neuronal substrate of classical conditioning in the hippocampus

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Science  30 Apr 1976:
Vol. 192, Issue 4238, pp. 483-485
DOI: 10.1126/science.1257783


Neuronal activity in dorsal hippocampus was recorded in rabbits-during classical conditioning of nictitating membrane response, with tone as conditioned stimulus and corneal air puff as unconditioned stimulus. Unit activity in hippocampus rapidly forms a temporal neuronal "model" of the behavioral response early in training. This hippocampal response does not develop in control animals given unpaired stimuli.