Ingestion of Streptococcus mutans induces secretory immunoglobulin A and caries immunity

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Science  18 Jun 1976:
Vol. 192, Issue 4245, pp. 1238-1240
DOI: 10.1126/science.1273589


Ingestion of killed cells of a highly cariogenic strain of Streptococcus mutans induced specific antibodies in both saliva and milk but not in serum of gnotobiotic rats. These antibodies were associated with the immunoglobulin A class. When infected with Streptococcus mutans, orally immunized animals developed significantly fewer carious lesions than nonimmunized infected controls.