Calcium release from skeletal muscle sarcoplasmic reticulum: site of action of dantrolene sodium

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Science  17 Sep 1976:
Vol. 193, Issue 4258, pp. 1130-1131
DOI: 10.1126/science.959824


The muscle relaxant dantrolene sodium acts directly and specifically on skeletal muscle, unlike other pharmacological agents which affect the central nervous system or act at the nueromuscular junction. Dantrolene sodium markedly suppresses the release of calcium previously sequestered by skeletal, but not cardiac, muscle sarcoplasmic reticulum. No effect in the total amount of calcium accumulated was found. In situ, the drug may reduce the amount of calcium necessary for muscle contraction.

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