Structural basis for ON-and OFF-center responses in retinal ganglion cells

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Science  08 Oct 1976:
Vol. 194, Issue 4261, pp. 193-195
DOI: 10.1126/science.959847


The inner plexiform layer of the mammalian retina has a bisublaminar organization determined by restricted branching of the terminals of cone bipolar cells and dendrites of class I (large) and class II (small) ganglion cells. Comparison of dendritic field diameters and receptive fiedl center sizes of large ganglion cells suggests that neural circuitry in sublamina a conveys "OFF"-center properties and connections in sublamina b "ON"-center properties to retinal ganglion cells.

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