(D-Ala2)-Met-enkephalinamide: a potent, long-lasting synthetic pentapeptide analgesic

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Science  15 Oct 1976:
Vol. 194, Issue 4262, pp. 330-332
DOI: 10.1126/science.968485


[D-Ala2]-Met-enkephalinamide (DALA), a synthetic enkephalin analog designed by in vitro analysis, binds to opiate receptors almost as tightly as methionine-enkephalin. Since it is not susceptible to degradation by brain enzymes, low doses (5 to 10 micrograms) cause profound, long-lasting, morphine-like analgesia when microinjected into rat brain.