Thyroxine-induced activation of hypothalamo-hypophysial axis in neotenic salamander larvae

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Science  29 Oct 1976:
Vol. 194, Issue 4264, pp. 525-527
DOI: 10.1126/science.973134


Thyroxine injected into the hypothalamus of neotenic Ambystoma tigrinum induces metamorphosis by activating hypothalamo-hypophysial stimulatory control of thyroid activity, thereby removing the hypothalamic block to metamorphosis.