Ovum aging and pH imbalance as a cause of chromosomal anomalies in the hamster

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Science  26 Nov 1976:
Vol. 194, Issue 4268, pp. 946-948
DOI: 10.1126/science.10628


Using female hamsters mated in estrus, we have produced triploid embryos as manifestations of pregnancy wastage by combining delays of 3 to 4 hours in ferilization with exposure of the animals to hypoxia. Among the triploid embryos only XXX and XXY karotypes occurred, indicating derivation from XX-containing ova. These findings have relevance to human reproduction.