Plasma alpha amino-n-butyric acid to leucine ratio: an empirical biochemical marker of alcoholism

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Science  03 Dec 1976:
Vol. 194, Issue 4269, pp. 1057-1058
DOI: 10.1126/science.824734


The plasma ratio of alpha-amino-n-butyric acid to leucine was elevated in ambulatory and hospitalized alcoholics as well as in baboons fed alcohol along with an adequate diet. There was a statistically significant positive correlation between this ratio and the degree of alcoholism assessed by three separate medical and psychological criteria in patients maintained on methadone.

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