Hypoxanthine-guanine phosphoribosyltransferase mutant glioma cells: diminished monamine oxidase activity

See allHide authors and affiliations

Science  10 Dec 1976:
Vol. 194, Issue 4270, pp. 1171-1173
DOI: 10.1126/science.996547


A defective capability of cultured rat glioma cells to reutilize purine bases (hypoxanthine-guanine phosphoribosyltransferase deficiency) was associated with a reduced capacity to oxidatively deaminate serotonin and tryptamine. The mutant glioma cells were also more sensitive to the cytotoxic effects of serotonin than were normal cells