Mesenchyme-dependent morphogenesis and epithelium-specific cytodifferentiation in mouse mammary gland

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Science  24 Dec 1976:
Vol. 194, Issue 4272, pp. 1439-1441
DOI: 10.1126/science.827022


Isografts of heterotypic recombinants of embryonic mammary epithelium with salivary mesenchyme undergo development morphogenetically resembling that of salivary gland. However, cytodifferentiation of the epithelium is like that of mammary gland. In lactating hosts these isografts respond to endogenous hormonal stimulation and synthesize a milk protein, alpha-lactalbumin.

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