Glutamine synthetase: glial localization in brain

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Science  25 Mar 1977:
Vol. 195, Issue 4284, pp. 1356-1358
DOI: 10.1126/science.14400


Light microscopy immunohistochemical techniques were used to examine the distribution of glutamine synthetase in rat brain. Glutamine synthetase was found to be localized in the glial cells. Neuronal cell bodies, endothelial cells, and choroid epithelium contained no enzyme. The findings indicate that glia have a crucial role in glutamic acid, gamma-aminobutyric acid, and ammonia metabolism in brain.

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