Antileukemia activity in the Osillatoriaceae: isolation of Debromoaplysiatoxin from Lyngbya

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Science  29 Apr 1977:
Vol. 196, Issue 4289, pp. 538-540
DOI: 10.1126/science.403608


Chloroform extracts of several seaweeds, of the family Oscillatoriaceae, from Enewetak Atoll, Marshall Islands, display activity against P-388 lymphocytic mouse leukemia. A P-388 active compound, debromoaplysiatoxin, has been isolated from Lyngbya gracilis and characterized. This compound also has dermonecrotic activity and may be the dermatitis-producing substance in L. majuscula, the causative agent of "swimmers' itch" outbreaks in Hawaiian waters.