Partial denervation affects both denervated and innervated fibers in the mammalian skeletal muscle

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Science  29 Apr 1977:
Vol. 196, Issue 4289, pp. 542-545
DOI: 10.1126/science.850797


Partial denervation of the rat extensor digitorum longus muscle was performed by sectioning only one of the sciatic nerve roots. Measurements of spike resistance to tetrodotoxin in individual muscle fibers revealed denervation changes not only in the denervated fibers but also in the adjacent innervated ones. The results support the concept that products of nerve degeneration play a role in the origin of muscle changes induced by denervation.