Thyrotropin-releasing hormone: stimulation of colonic activity following intracerebroventricular administration

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Science  06 May 1977:
Vol. 196, Issue 4290, pp. 660-662
DOI: 10.1126/science.404705


Intraventricularly administered thyrotropin-releasing hormone in rabbits elicited an increase in intraluminal pressure changes, a response commonly associated with muscular activity of the colon. The response appears to be central in origin with peripheral expression relying primarily on cholinergic receptors.