Drug tolerance in biomembranes: a spin label study of the effects of ethanol

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Science  06 May 1977:
Vol. 196, Issue 4290, pp. 684-685
DOI: 10.1126/science.193186


Ethanol in vitro increased the fluidity of spin-labeled membranes from normal mice. Membranes from mice that had been subjected to long-term ethanol treatment were relatively resistant to this fluidizing effect. The data suggest that the membranes themselves had adapted to the drug, a novel form of drug tolerance.

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