Steroid contraceptive use and cervical dysplasia: increased risk of progression

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Science  24 Jun 1977:
Vol. 196, Issue 4297, pp. 1460-1462
DOI: 10.1126/science.867043


In a prospective study of women with dysplasia of the cervix, there was an increase in severity of dysplasia and of conversion to cancer in situ in users of the contraceptive pill compared with users of other contraceptive methods. There was a delay in this adverse response. Nonreversal of dysplasia within the first 6 months of pill use is predictive of progression after prolonged exposure.