Somatostatin: electron microscope immunohistochemical localization in secretory neurons of rat hypothalamus

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Science  24 Jun 1977:
Vol. 196, Issue 4297, pp. 1469-1470
DOI: 10.1126/science.867046


Somatostatin, the hypothalamic hormone which inhibits the secretion of growth hormone by the pituitary, has been localized in the rat hypothalamus by using electron microscope immunohistochemistry. Somatostatin occurs in secretory granules (80 to 110 nm in diameter) of a few neurons located in the hypothalamic periventricular nucleus. These observations establish the identity of neurosecretory neurons involved in the regulation of adenohypophyseal secretion.