Cannabinoids inhibit testosterone secretion by mouse testes in vitro

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Science  24 Jun 1977:
Vol. 196, Issue 4297, pp. 1472-1473
DOI: 10.1126/science.867048


Addition of delta-9-tetrahydrocannabinol or cannabinol to an incubation medium containing decapsulated mouse testes caused a significant reduction in the accumulation of testosterone in the medium. This result suggests that the reported effects of cannabis on male sexual and reproductive function may result from direct inhibition of testicular steroidogenesis by both psychoactive and nonpsychoactive constituents of marihuana.