Transport interaction of cystine and dibasic amino acids in renal brush border vesicles

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Science  08 Jul 1977:
Vol. 197, Issue 4299, pp. 169-171
DOI: 10.1126/science.877548


The uptake of cystine by vesicles prepared from rat kidney brush borders occurs by two distinct transport systems. The higher affinity system is inhibited by the dibasic amino acids lysine, arginine, and ornithine. The lower affinity system, unaffected by dibasic amino acids, appears to correspond to that observed by studying uptake of cystine by kidney slices.